Posted By: Alyson Barnes, PhD, Assistant Editor, AJHG AB: What motivated you to start working on this project? KF: Our research group’s primary focus is to use artificial intelligence and deep learning-based approaches to study clinically-relevant genetics questions. This specific project is motivated by the rapid increase in the use of large language models (LLMs)... Read More
Posted By: Kylee Spencer, PhD, Assistant Editor, AJHG KS: What motivated you to start working on this project? MG: During the pandemic, I found myself at home with three kids under five and adjusting to a totally new type of “normal,” which drove me to reprioritize my research goals. Being physically away from the bench,... Read More
Posted By: Kylee L. Spencer, PhD, Assistant Editor, AJHG KLS: What motivated you to start working on this project? EAS: Over the past 14 years conducting research in Africa, I’ve heard the same frustrations from African colleagues about insufficient funding for research, a lack of lab resources and infrastructure, and limited opportunities for advanced training.... Read More
Posted By: Kylee Spencer, PhD, Assistant Editor, AJHG KS: What motivated you to start working on this project? AP: I‘ve had an interest in structural variants (SVs) ever since working on microdeletions identified in array data from the Autism Genomes Project. Now that large clinical genome sequencing datasets are available via the 100k Genomes Project,... Read More
Posted By: Kylee Spencer, PhD, Assistant Editor, AJHG KS: What motivated you to start working on this project? YL and QS: Genotype imputation is a standard practice but not all variants can be well imputed. State-of-the-art approaches perform poorly for low frequency variants (LFVs) and rare variants (RVs), either removing well-imputed variants or failing to... Read More
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